Contrave: What It Is, How It Works, and How to Use It Safely

If you’ve been hunting for a prescription aid to cut those stubborn pounds, you’ve probably seen the name Contrave. It’s a combo of bupropion and naltrexone, two drugs that each target different brain pathways that control appetite and cravings. The result is a pill that can help you feel fuller sooner and curb the urge to snack.

Who Should Consider Contrave?

Contrave is approved for adults with a body‑mass index (BMI) of 30 or higher, or a BMI of 27‑29.9 plus at least one weight‑related condition such as high blood pressure, type 2 diabetes, or high cholesterol. If you fit that profile and have tried diet and exercise alone without lasting results, your doctor may suggest Contrave as part of a broader weight‑management plan.

People with a history of seizures, eating disorders, or uncontrolled mental health issues should avoid it. It also isn’t safe during pregnancy, while breastfeeding, or if you’re taking monoamine oxidase inhibitors (MAOIs). Always share your full medical history before starting.

How to Take Contrave: Dosage and Timing

The typical schedule ramps up over four weeks to let your body adjust:

• Week 1‑2: 1 tablet in the morning (8 mg bupropion + 8 mg naltrexone)
• Week 3‑4: 1 tablet in the morning + 1 tablet at night (16 mg + 16 mg each)
• Week 5 onward: 2 tablets in the morning + 2 at night (32 mg + 32 mg each)

Take the pills with food to lessen stomach upset. If you miss a dose, take it as soon as you remember—unless it’s close to your next scheduled dose, then just skip the missed one. Never double up.

Stick to the prescribed amount. Taking more won’t speed up weight loss and only raises the risk of side effects such as increased blood pressure, rapid heart rate, or mood swings.

Common Side Effects (And How to Manage Them)

Most users experience mild issues that fade in a few weeks. Expect:

• Nausea or stomach discomfort
• Headache
• Dizziness
• Dry mouth
• Insomnia (try taking the night dose earlier or split it differently)

If you develop severe nausea, persistent vomiting, or signs of an allergic reaction—rash, swelling, trouble breathing—stop the medication and call your doctor right away.

Stay hydrated, eat small balanced meals, and avoid alcohol while on Contrave. Alcohol can boost the risk of liver issues and worsen side effects.

Practical Tips for Getting the Most Out of Contrave

Contrave works best when paired with lifestyle changes. Keep a food journal for the first month to spot hidden calories. Aim for at least 150 minutes of moderate‑intensity activity a week—walking, cycling, or dancing all count.

Set realistic goals: a 5‑10 % weight loss over six months is a solid target. Celebrate small wins, like fitting into an old pair of jeans or noticing lower blood‑sugar readings.

Regular check‑ins with your healthcare provider are key. They’ll track your weight, blood pressure, and any side effects, tweaking the dose if needed.

Remember, Contrave isn’t a magic pill. It’s a tool that can tip the scale in your favor when you pair it with healthier habits. Talk to your doctor to see if it’s right for you, follow the dosing plan, watch for side effects, and stay consistent with diet and exercise. With the right approach, you’ll give yourself the best shot at lasting weight loss.