Contrave Side Effects – What to Expect & How to Manage

If you’ve started Contrave for weight loss, you probably know it’s a combo of bupropion and naltrexone. The drugs can help shrink appetite, but they also bring a set of side effects. Knowing what’s normal and what needs a doctor’s call can save you stress and keep you on track.

Common side effects you’ll likely notice

Most people feel one or two of these within the first few weeks:

• Nausea or an upset stomach – a queasy feeling that usually eases after a few days.
• Headache – often mild, but can be annoying if you’re busy.
• Dry mouth – sip water or chew sugar‑free gum to keep the feelers down.
• Constipation or diarrhea – stay hydrated and add fiber to balance it out.
• Insomnia – taking the dose earlier in the day can help you sleep better.
• Dizziness – stand up slowly and avoid driving until you know how you feel.

These symptoms are usually short‑lived. If they stick around past two weeks, talk to your pharmacist or doctor.

Less common but serious effects

Rarely, Contrave can cause problems that need urgent attention:

• Increased blood pressure or rapid heart rate – check your vitals regularly, especially if you have heart history.
• Severe mood changes – anxiety, agitation, or thoughts of self‑harm should never be ignored.
• Liver issues – yellow skin or dark urine may signal trouble.
• Allergic reactions – rash, itching, swelling, or breathing difficulty require immediate care.

If any of these appear, call your doctor right away or head to urgent care.

Why do these happen? Bupropion affects brain chemicals that control mood and appetite, while naltrexone touches opioid receptors that can flip blood pressure and mood balance. The mix works for weight loss but also nudges other body systems.

Here’s how to manage the common stuff:

• Take the medication with food if nausea hits you – a light snack can calm the stomach.
• Keep a water bottle handy. Sipping often reduces dry mouth and helps with constipation.
• Set a regular bedtime and avoid caffeine after noon to curb insomnia.
• Check your blood pressure at home once a week; report any upward trend.
• Write down any mood swings, even if they seem small. Your doctor can adjust the dose before it grows serious.

Don’t stop the pill on your own. Cutting it off abruptly can cause withdrawal‑type symptoms and undo the progress you’ve made. If side effects are unbearable, your doctor can taper you off safely or switch to a different plan.

Remember, every body reacts differently. Some people feel almost nothing, while others notice a few bumps. Staying informed, tracking how you feel, and keeping the conversation open with your healthcare team will give you the best chance to keep the benefits and lose the drawbacks.

Bottom line: Contrave can be a useful tool for weight loss, but it comes with a predictable set of side effects. Spot the common ones, watch for the rare red flags, and act promptly. With a little vigilance, you can stay on track without unwanted surprises.